TB-500
Product Overview
TB-500 is a short, synthetic peptide fragment representing the active binding domain of Thymosin Beta-4, an essential regenerative protein present in virtually all human and animal cells. Unlike larger proteins, the low molecular weight of TB-500 allows for high systemic mobility, allowing it to move easily through target tissues during experimental research.
The primary mechanism of TB-500 centers on its interaction with actin, a structural monomeric protein critical for cell motility, cytoskeletal architecture, and wound healing cascades. In laboratory models, TB-500 exposure has been shown to accelerate endothelial and fibroblast cell migration to sites of tissue stress, while simultaneously downregulating inflammatory cytokines. Researchers utilize this compound to explore biological pathways involved in soft tissue restoration, flexibility, and the acceleration of structural repair mechanisms.
Research Applications
TB-500 is commonly utilized in laboratory settings for investigations involving:
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Actin regulation and cellular motility models
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Angiogenesis and localized microvascular development
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Fibroblast and endothelial cell migration studies
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Regeneration and healing cascades of tendons, ligaments, and muscle tissue
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Reduction of inflammatory cytokines and oxidative stress signaling
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Reorganization of the extracellular matrix to minimize fibrotic scarring
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Preclinical cardiovascular and neurological tissue repair models
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Joint mobility and structural flexibility optimization in animal models
Researchers continue to explore TB-500’s interactions with various biological systems to better understand its potential applications in preclinical and translational research environments.
Peptide Information
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Peptide Name: TB-500 (Thymosin Beta-4 Fragment)
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Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala
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Molecular Classification: Acetylated Synthetic Heptapeptide
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Research Category: Tissue Repair and Cellular Migration Research Peptide
Storage
Store lyophilized TB-500 in a cool, dry environment away from direct light. For long-term storage, refrigeration or freezing is recommended according to established laboratory protocols.
Research Use Only
This product is intended exclusively for laboratory research and analytical purposes.
Not for human consumption. Not for medical, veterinary, household, cosmetic, or food use. This product is not a drug and has not been approved by the U.S. Food and Drug Administration for the diagnosis, treatment, cure, or prevention of any disease. All purchasers are responsible for ensuring compliance with applicable laws and regulations governing research compounds.





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